High-Density
Lipoprotein (HDL) Cholesterol
Released on
= July 11, 2005, 4:18 am
Press Release
Author = Lipidhealth
Industry = Healthcare
Press Release
Summary = The Role of High-Density Lipoprotein (HDL) Cholesterol
Press Release
Body = The Role of High-Density Lipoprotein (HDL) Cholesterol
High-density
lipoproteins (HDL) have an important role to play especially in
the prevention and treatment of coronary heart disease. The role
of this important lipoprotein can be further enumerated below.
HDL and its
working
HDL are the smallest and densest of all lipoproteins and have the
highest proportion of proteins. It has the capability of picking
up cholesterol, which is carried, internally from the cells it interacts
with. These are considered to be good lipoproteins as they carry
cholesterol from the body's tissues to the liver for excretion.
Once cholesterol combines with HDL, a plasma enzyme called lecithin:
cholesterol acyltransferase (LCAT) acts to convert the free cholesterol
into cholesteryl ester. Cholesteryl ester is a more hydrophobic
form of cholesterol and is sequestered into the core of the lipoprotein
particle. This leads to the final synthesis of the new HDL spherical.
As it circulates through the bloodstream, the HDL spherical further
increases in size by internalizing more cholesterol molecules finally
reaching the liver for excretion.
Prevention of
coronary heart disease Coronary heart disease (CHD) is caused by
the accumulation of atheromatous plaques within the walls of the
arteries that supply the myocardium or the muscle of the
heart. After decades of progression, some of these atheromatous
plaques may rupture and cause the activation of the blood clotting
system. This then starts to limit blood flow to the heart muscle.
HDL help to remove cholesterol from atheroma within
the arteries, and transport it back to the liver for excretion.
Studies reveal that the HDL level in men is much lower, with smaller
size & lower cholesterol content, than women. Thus men also
have an increased risk and incidence of heart diseases.
Studies demonstrate that high concentrations of HDL ranging over
60 mg/dL tend to protect against cardiovascular diseases. Low concentrations
on the other hand at a range below 40 mg/dL for men and below 50
mg/dL for women can prove to be a high
risk factor.
Treatment
Patients with coronary heart disease or those at risk can increase
the amount of HDL in their body. This can be attained by avoiding
readily oxidized fats like saturated fats and trans-fats. Limited
use of carbohydrates and processed sugars also helps to
reduce production of Low-density lipoproteins while increasing High-density
lipoproteins. Keeping blood pressure at normal, exercising and quitting
smoking can also help to limit the progression of the disease.
Lipidhealth.org
is dedicated to battling the disease, by its prevention and treatment
through safe and effective methods. Our panel of experts works and
guides patients on the right attitude, lifestyle and treatment options.
Web Site = http://www.lipidhealth.org
Contact Details
= meenakshi@mosaic-service.com
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