Released on = December 11, 2006, 10:57 am

Press Release Author = Anaspec

Industry = Biotech

Press Release Summary = The substitution of the fluorine in place of hydrogen in
building blocks, such as amino acids, has produced molecules with enhanced
physiological activities (1-2).

Press Release Body = Fluorinated Building Blocks Produce Molecules with Enhanced
Physiological Activities

San Jose, CA - December 4, 2006

The substitution of the fluorine in place of hydrogen in building blocks, such as
amino acids, has produced molecules with enhanced physiological activities (1-2).
Some of these are antibacterial, antihypertensive and antitumoral (3). One reason
for the enhanced activity is that fluorine forms a strong covalent bond with a
carbon atom, which in peptides creates hyper-stable protein folds that render fluoro
amino acid-containing peptides resistant to metabolic transformation (2, 4). The
electronegativity of fluorine affects the pH of the neighboring groups, which in
turn causes an overall change in the stability and reactivity of a molecule (2).

AnaSpec, a worldwide provider of integrated proteomics solutions, offers a wide
collection of fluorinated amino acids.

Selected Listing of Fluorinated Amino Acids

Fmoc-3-amino-4,4,4-trifluorobutyric acid
100 mg 26235-F01
250 mg 26235-F025
500 mg 26235-F05
Boc-3-amino-4,4,4-trifluorobutyric acid
100 mg 26235-B01
250 mg 26235-B025
500 mg 26235-B05
Fmoc-2-amino-5-fluorobenzoic acid
1 g 26028-F1
5 g 26028-F5
Boc-2-amino-5-fluorobenzoic acid
1 g 26028-B1
5 g 26028-B5
Fmoc-3,4-difluoro-L-phenylalanine
1 g 26719-F1
5 g 26719-F5
Boc-3,4-difluoro-L-phenylalanine
1 g 26719-B1
5 g 26719-B5
Fmoc-3,4-difluoro-D-phenylalanine
1 g 26720-F1
5 g 26720-F5
Boc-3,4-difluoro-D-phenylalanine
1 g 26720-B1
5 g 26720-B5
Fmoc-2-fluoro-L-phenylalanine
1 g 26081-F1
5 g 26081-F5
Boc-2-fluoro-L-phenylalanine
1 g 26081-B1
5 g 26081-B5
Fmoc-5-fluoro-DL-tryptophan
100 mg 26171-F01
1 g 26171-F1
Boc-5-fluoro-DL-tryptophan
100 mg 26171-B01
1 g 26171-B1
Fmoc-6-fluoro-DL-tryptophan
100 mg 26172-F01
1 g 26172-F1
Boc-6-fluoro-DL-tryptophan
100 mg 26172-B01
1 g 26172-B1
Fmoc-3-fluoro-DL-tyrosine
100 mg 26085-F01
1 g 26085-F1
Boc-3-fluoro-DL-tyrosine
100 mg 26085-B01
1 g 26085-B1


For a complete listing, click here:

For more information, visit www.anaspec.com


References:
1. Welch, JT. Tetrahedron 43, 3123 (1987).
2. Sutherland, A. and CL. Willis. Nat. Prod. Rep. 17, 621 (2000).
3. Davis, FA. et al. J. Org. Chem. 64, 6931 (1999).
4. Yoder, NC. And K. Kumar. Chem. Soc. Rev. 31, 335 (2002).



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