AnaSpec Introduces Acetylated and Methylated Lysines
Released on = July 26, 2007, 8:37 am
Press Release Author = AnaSpec Inc.
Industry = Biotech
Press Release Summary = AnaSpec has introduced acetylated, mono-methylated, di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The use of these building blocks, although not limited to making synthetic histone peptides, provides additional tools for researchers to help unravel the "histone code."
Press Release Body = July 23, 2007 - San Jose, CA AnaSpec has introduced acetylated, mono-methylated, di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The use of these building blocks, although not limited to making synthetic histone peptides, provides additional tools for researchers to help unravel the "histone code."5 The lysine-rich amino terminal tail of the core histones undergo posttranslational modifications such as acetylation and methylation.1-2 Addition of acetyl group or 1 to 3 methyl groups occur at position specific lysines.3-4 These modifications, as well as phosphorylation of serine residues and others, serve to differentially regulate chromatin activity.5 Acetylated Lysines Fmoc-Lys(Ac)-OH Boc-Lys(Ac)-OH
Methylated Lysines Fmoc-Lys(Me, Boc)-OH Fmoc-Nε,ε-dimethyl-L-lysine hydrochloride salt Boc-Nε,ε-dimethyl-L-lysine hydrochloride salt Fmoc-Lys(Me)3-OH chloride
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