Released on = July 11, 2007, 8:36 am

Press Release Author = AnaSpec Inc.

Industry = Biotech

Press Release Summary = At the 2007 annual conference of the American Peptide
Society, AnaSpec presented a "late-breaking" technical poster that described in vivo
imaging using a tissue-specific near infrared fluorescent peptide conjugate.

Press Release Body = July 10, 2007 - Montreal, QC, Canada

At the 2007 annual conference of the American Peptide Society, AnaSpec presented a
"late-breaking" technical poster that described in vivo imaging using a
tissue-specific near infrared fluorescent peptide conjugate.

Extracellular matrix proteins that contain the Arg-Gly-Asp (RGD) sequence,
and integrin receptors which bind this sequence, constitute a major recognition
system for cell migration and adhesion processes. In fibronectins and other
proteins, the RGD binding sequence is found at the apex of a loop; such
conformation has been found to allow for high affinity selectivity to integrin
receptors. Cyclic peptides have been shown to be more stable than linear
peptides; in the case of RGD cyclic peptide c(RGDyK), its structure also confers
increased affinity and selectivity for integrin αvβ3 both in cell culture
and in living
subjects.

The AnaSpec poster described in vivo testing of an RGD cyclic peptide labeled with a
proprietary near infrared fluorescent dye, HiLyte FluorTM 750-labeled RGD
peptide, c[RGDyK(HiLyte FluorTM 750)], with excitation and emission wavelengths
at 750 and 780 nm. Results demonstrated that in an animal model, this conjugate bound
specifically to some tissues in organs that are known to be rich in integrin
αvβ3.

For more information visit www.anaspec.com

Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents, and combinatorial chemistry.
Established in 1993, AnaSpec\'s headquarters and manufacturing facilities are located
in San Jose, CA.


Web Site = http://www.anaspec.com

Contact Details = Ping Yang
2149 O\'toole Ave.
San Jose, CA 95131
1-408-452-5055
ping@anaspec.com