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AnaSpec Introduces Collection of Channel Blocker Peptides

Released on: February 19, 2008, 8:53 am

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: AnaSpec has introduced its selection of channel blocker
peptides.

Press Release Body: San Jose, CA - February 18, 2008

AnaSpec, one of the world's largest providers of catalog peptides, has introduced
its selection of channel blocker peptides.

Peptide toxins are potent and selective compounds that can act on ion channels in
plasma membrane of excitable cells.1 These high specificity and affinity compounds,
often with diverse and selective pharmacologies, are used as pharmacological probes
to study and characterize various receptor proteins involved in ion-channel
function.1 These toxin peptides generally consist of a relatively small number of
structural frameworks that are particularly suited to addressing the crucial issues
of potency and stability.1 Multiple disulfide bonds constitute essential structural
elements in many of these bioactive peptides, which are generated by proteolytic
processing of prefolded protein precursors and then released from the cells in the
bioactive form into the extracellular medium to exert their physiological function.

Ca2+ Channel Blockers
ω-Conotoxin GVIA
ω-Conotoxin MVIIC
ω-Conotoxin MVIIA
Imperatoxin A (IpTxa)
Ryanodine receptor agonist


K+ Channel Blockers
Iberiotoxin (IbTX)
Charybdotoxin
[Glu32]-Charybdotoxin
Apamin
Mast Cell Degranulating Peptide, MCD

Cl-Channel Blocker
Chlorotoxin (Cltx)

Other Ion Channel Blockers
Conantokin G
Sarafotoxin 6C
[Lys4]-Sarafotoxin 6c
Beauvericin

Company Info

AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry.
For more information, visit www.anaspec.com

Reference:
1. Lewis, RJ. and ML. Garcia, Nat. Rev. Drug Discov. 2, 790 (2003).




Web Site: http://www.anaspec.com

Contact Details: AnaSpec Inc.
2149 O\'Toole Ave.
San Jose, CA 95131
ping@anaspec.com

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