Released on: March 27, 2008, 2:05 pm

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: Recognizing the need for versatile tools for the detection of
calcium, AnaSpec offers Fluo-3, a high affinity fluorescent calcium indicator.

Press Release Body: San Jose, CA - March 27, 2008

Calcium plays a vital role in the specific and selective regulation of major
cellular processes and is central in the regulation of cardiac contractility, growth
and gene expression. Calcium indicators are small molecules that can respond to the
binding of Ca2+ ions by changing their spectral properties. Recognizing the need
for versatile tools for the detection of calcium, AnaSpec offers Fluo-3, a high
affinity fluorescent calcium indicator.

Fluo-3 absorbs at approximately 506 nm and emits at 526 nm when bound to calcium. In
the absence of calcium it is practically non-fluorescent. The higher Kd and longer
excitation wavelength of Fluo-3 can have significant advantages over other
indicators because of the reduced interference with sample autofluorescence. It
demonstrates efficient excitation with laser-based instrumentation, including
confocal laser scanning microscopes. It has been widely used for flow cytometry and
is one of the imaging methods of intracellular calcium flux that is associated with
GPCR dynamics.
Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry.

For more information, visit www.anaspec.com




Web Site: http://www.anaspec.com

Contact Details: AnaSpec Inc.
2149 O\'Toole Ave.
San Jose, CA 95131
1-408-452-5055 (Tel)
1-408-452-5059 (Fax)
1-800-452-5530
ping@anaspec.com
www.anaspec.com