Released on: March 28, 2008, 4:44 pm

Press Release Author: GTCbio

Industry: Biotech

Press Release Summary: Dr. Xi Chen, Assistant Professor in the Department of
Chemistry at the University of California, Davis will present at GTCbio's 3rd Assay
Development & Screening Technologies Conference on June 5-6, 2008 in San Francisco,
CA. Dr. Chen will speak on combinatorial chemoenzymatic synthesis and
high-throughput screening of carbohydrates.


Press Release Body: Dr. Xi Chen, Assistant Professor in the Department of Chemistry
at the University of California, Davis will present at GTCbio's 3rd Assay
Development & Screening Technologies Conference on June 5-6, 2008 in San Francisco,
CA. Dr. Chen will speak on combinatorial chemoenzymatic synthesis and
high-throughput screening of carbohydrates.

Although the vital roles of carbohydrates in biomolecular recognition are well
documented, limited information is available on how the structures of carbohydrates
(e.g. the terminal monosaccharide structures, glycosyl linkages, and the underlying
glycan structures) affect their binding to carbohydrate-recognizing proteins and
influence related downstream biological processes. A novel combinatorial
chemoenzymatic method has been developed for highly efficient synthesis of
biotinylated oligosaccharides in 96-well plates. By transferring the reaction
mixtures to Neutravidin-coated plates and assaying for the yields of enzymatic
reactions using lectins binding to glycosyltransferase acceptors, the biotinylated
glycosylated products can be directly used, without purification, for
high-throughput screening to quickly identify the ligand specificity of
product-binding proteins. This method is very efficient in producing a large library
of oligosaccharides for direct structure-function studies.

GTCbio\'s 3rd Assay Development and Screening Technologies conference will provide
attendees with critical information to utilize in the discovery and development of
assays, while keeping them informed about the latest screening technologies for both
high-throughput screening and high-content screening. Topics being covered include
cell based assays, high throughput screening, high content screening, in vitro
assays and screening, novel assay and screening technologies, and target validation.
For more information visit www.gtcbio.com.
ABOUT GTCbio
GTCbio organizes conferences specifically for the biomedical and biopharmaceutical
industries. Our goal is to facilitate the exchange of biopharmaceutical and
biomedical intelligence between industry leaders, academic and government
organizations, and the financial community.
GTCbio is a subsidiary of Global Technology Community, LLC, a privately held company
founded in 2002.
Contact: GTCBIO (626) 256-6405, (626) 256-6460 fax, nina.tran@gtcbio.com


Web Site: http://www.gtcbio.com

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Monrovia, Ca 91016