Released on: April 21, 2008, 3:05 pm

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: AnaSpec FRET-based MMP substrates were recently used in a
double differential in vivo zymography study at the University of New Brunswick.

Press Release Body: San Jose, CA - April 21, 2008

Utilizing AnaSpec's proprietary detection technologies, AnaSpec FRET-based MMP
substrates were recently used in a double differential in vivo zymography study at
the University of New Brunswick.

In the study by Dr. Bryan Crawford, a mixture of QXLT 570/5-TAMRA-labeled Peptide I
incorporating a red fluorophore, and QXLT 520/5-FAM-labeled Peptide XIII
incorporating a green fluorophore were used to detect differential breakdown of the
two different MMP substrates in zebrafish. Peptide I was broken down mostly in the
maturing myotome boundaries, whereas Peptide XIII was broken down much more strongly
in the notochord sheath.

Synthetic FRET peptide substrates provide a reliable method for monitoring enzyme
activity by following substrate cleavage. Through the innovative work of researchers
such as Dr. Crawford, the applications of AnaSpec's FRET technologies continue to be
expanded.
Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry.

For more information, visit www.anaspec.com


Web Site: http://www.anaspec.com

Contact Details: AnaSpec Inc.
2149 O\'Toole Ave.
San Jose, CA 95131
1-408-452-5055 (Tel)
1-408-452-5059 (Fax)
1-800-452-5530
ping@anaspec.com
www.anaspec.com