Released on: June 18, 2008, 2:08 pm

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: The innovative technique of hydrocarbon stapling in peptides
is introducing valuable new functionality to peptide-related research. AnaSpec is
pleased to offer custom synthesis for hydrocarbon-stapled peptides.

Press Release Body: San Jose, CA - Jun 18, 2008
The innovative technique of hydrocarbon stapling in peptides is introducing valuable
new functionality to peptide-related research. AnaSpec is pleased to offer custom
synthesis for hydrocarbon-stapled peptides.
Hydrocarbon-stapled peptides are peptides capable of forming stable alpha helical
structure as a result of "hydrocarbon stapling."1,2 Many biological pathways, such
as signal transduction, occur because of intracellular protein-protein interactions,
which frequently are mediated by the a-helix structures of proteins; however, the
use of short protein fragments (peptides) leads to a loss of secondary structure,
such as alpha helical structure. Short peptides are easily degraded by proteolysis
and have difficulty in intact cells penetration.1 Verdine's group has shown that
these problems could be overcome by a chemical modification of an alpha-helical
peptide they termed hydrocarbon-stapled peptide.1,2 The modified hydrocarbon-stapled
peptide is helical, relatively protease resistant, cell-permeable and binds with
increased binding affinity to its target. Hydrocarbon stapling may provide a useful
strategy in researching experimental and therapeutic modulation of protein-protein
interactions as well as in in vivo pharmacokinetics studies.
Company Info
AnaSpec, Inc. is a leading provider of integrated proteomics solutions to
pharmaceutical, biotech, and academic research institutions throughout the world.
With a vision for innovation through synergy, AnaSpec focuses on three core
technologies: peptides, detection reagents (dyes, assay kits, & antibodies), and
combinatorial chemistry.
For more information, visit www.anaspec.com
References:
1. Walensky, LD. et al. Science 305, 1466 (2004).
2. Schafmeister, CE. et al. J. Am. Chem. Soc. 122, 5891 (2002).
3. Qiu, W. et al. Tetrahedron 56, 2577 (2000).
4. Belokon, Y. N. et al. Tetrahedron: Asymmetry 9, 4249 (1998).



Web Site: http://www.anaspec.com

Contact Details: AnaSpec Inc.
2149 O\'Toole Ave.
San Jose, CA 95131
1-408-452-5055 (Tel)
1-408-452-5059 (Fax)
1-800-452-5530
ping@anaspec.com
www.anaspec.com